|
Troglitazone
Description
A novel antidiabetic agent. It is found to exert significant cell cycle arrest and apoptosis in hepatocellular carcinoma cell lines. It has a unique property of selectively inducing EGR-1 gene independent of PPARg. Potential preventive agent for colon carcinogenesis.
Specifications
Cas No. 97322-87-7
Product ID T7056
Product Name Troglitazone
Chemical Name 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl- 2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4- thiazolidinedione
Synonym Noscal; Prelay; Rezulin; Romozin
Formula Wt. 441.54
Melting Point 184oC-186oC
Purity ≥98%
Solubility Soluble in DMSO, and dimethyl formide. Slightly soluble in 100% ethanol.
Store Temp Ambient
References Fugiwara T, Horikoshi H. Life Sci. 67:2405-16 (2000). Baek SJ, Wilson LC, His LC, Eling TE. J Biol Chem. Dec 9 (2002). Osawa E, et.al. Gastroenterology 124:361-367 (2003).
|