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Beauvericin
Description
Beauvericin, a cyclic hexadepsipeptide with alternating L-N-methylphenylalanyl and D-a-hydroxyisovaleryl residues, is a mycotoxin derived from the mould Beauveria bassiana, Fusarium strains and other moulds. Beauvericin shows cytotoxic, Immunosuppressant, and apoptotic activity. It is the most potent specific inhibitor of cholesterol acyltransferase and possesses ionophoric properties. It increases ion permeability in biological membranes by forming a complex with essential cations (Ca2+, Na+, K+), which may affect the ionic homeostasis.
Specifications
Cas No. 26048-05-5
Product ID B1603
Product Name Beauvericin
Formula Wt. 783.95
Purity ≥95%
Solubility Insoluble in water. Soluble in organic solvents.
Store Temp +4°C
Ship Temp Ambient
References Chen BF, Tsai MC, Jow GM. 2006 Feb 3;340(1):134-9. Kouri K, Duchen MR, Lemmens-Gruber R. Chem Res Toxicol. 2005 Nov;18(11):1661-8 Lin HI, Lee YJ, Chen BF, Tsai MC, Lu JL, Chou CJ, Jow GM. Cancer Lett. 2005 Dec 18;230(2):248-59.
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