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Aristolochic acid A
Description
Aristolochic acids are the active ingredients responsible for the hepatoxicity and renal toxicity of the Oriental herb Aristolochic fangchi. They form DNA adducts in renal tissue and is associated with urothelial carcinoma formation. They are known to induce hepatic nodules and forestomach tumors in rats. Aristolochic acid A activates rats genes in tumors.
Specifications
Cas No. 313-67-7
Product ID A6932
Product Name Aristolochic acid A
Chemical Name 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid
Synonym Aristolochic acid; Aristolochin Birthwort; Tardolyt
Formula Wt. 341.27
Melting Point 281oC-286oC(dec.)
Purity 95%
Solubility Soluble in DMSO or ethanol.
Store Temp -20oC
Ship Temp Ambient
References Levi, M., Guchelaar, H.J., Woerdenbag, H.J. Zhu, Y.P. Pharm. World Sci. 20:43-44 (1998). Schmeiser, H.H., Bieler, C.A. Wiessler, M., et al. Cancer Res. 56:2025-2028(1996). Nortier, J.L., Martinez, M.C., Schmeiser, H.H., et al. New England J. Med. 342:
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