Brefeldin A

产品编号：	B-8500-1 g 查看说明书
产品名称：	Brefeldin A .0 订购此产品
供应商：	LC
规格：	1 g
目录价：	45342
库存状态：
CAS编号：	[20350-15-6]
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相关信息：
B-8500 Brefeldin A, >99% [Decumbin] [Ascotoxin] [Cyanein] [Nectrolide] [Synergisidin] [BFA] M.W. 280.36 C16H24O4 [20350-15-6] RTECS: GY8410000 M.I. 11: 1363 M.I. 14: 1369 Warning: Toxic. Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes." J. Biol. Chem. 261: 11398-11403 (1986). •Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245: 57-68 (1998). •Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. "Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking." Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Membr. Cell Biol. 13: 303-320 (2000). •Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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