Bryostatin 1

产品编号：	B-6697-300 μg 查看说明书
产品名称：	Bryostatin 1 .0 订购此产品
供应商：	LC
规格：	300 μg
目录价：	19786
库存状态：
CAS编号：	[83314-01-6]
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相关信息：
B-6697 Bryostatin 1, >99% [B705008K112] M.W. 905.03 C47H68O17 [83314-01-6] M.I. 13: 1442 M.I. 14: 1457 Note: Binds to glass and plastic surfaces in aqueous solutions. Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A Bryostatin 1 binds to and activates protein kinase C, but its biological effects differ greatly from those induced by other protein kinase C activators. Bryostatin 1 fails to mimic many effects caused by PMA and actually blocks some PMA-induced response in a variety of cells and tissues. Kraft, A.S., et al. "Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60." Proc. Natl. Acad. Sci. USA 83: 1334-1338 (1986). Sako, T., et al. "Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells." Cancer Res. 47: 5445-5450 (1987). Dell'Aquila, M.L., et al. "Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells." Cancer Res. 47: 6006-6009 (1987). Hess, A.D., et al. "Activation of human T lymphocytes by bryostatin." J. Immunol. 141: 3263-3269 (1988). • The true affinity of bryostatin 1 for PDBu binding site on PKC appears to be in the low picomolar range or lower. de Vries, D.J., et al. "Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain." Biochem. Pharmacol. 37: 4069-4073 (1988). •See technical Note #1 for additonal information. •Please note: The correct molecular weight for bryostatin I is 905.04. Perhaps the M.W. 887 error found in other catalogs arises because the original publication describing bryostatin I mentions a mass spectrum peak at 887, but apparently that peak resulted from the loss of one water molecule during the mass spectral process. •Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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