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Arachidonoyl Glycine-d8
Cayman Chemical Item Number 10007531
Description Arachidonoyl glycine-d8 (NAGly-d8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of NAGly by GC- or LC-mass spectrometry. NAGly has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA),1↗ from extracts of mammalian brain,2↗,3↗ and has also been synthesized as an analog of AEA for structure/activity testing.4↗ NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl coenzyme A. NAGly is reported to have analgesic activities in whole animal experiments.1↗,2↗,3↗ Since it seems to be a very poor ligand for the CB1 receptor,4↗ these effects are probably mediated via other signalling pathways.
Synonyms NAGly-d8
N-Arachidonyl Glycine-d8
Formal Name N-[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]-glycine,5,6,8,9,11,12,14,15-d8
CAS Number 1159908-44-7
Molecular Formula C22H27D8NO3
Formula Weight 369.6
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O
InCHI Code 1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-/i6D,7D,9D,10D,12D,13D,15D,16D
InCHI Key YLEARPUNMCCKMP-FBFLGLDDSA-N |