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Araguspongin B
Cayman Chemical Item Number 10006797
Description
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1↗ Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2↗ Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM.3↗ It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
Formal Name
[1R-(1R*,4aR*,11S*,12aR*,13R*,16aR*,23S*,24aR*)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b’]dipyridine
CAS Number 123000-02-2
Molecular Formula C28H51N2O2
Formula Weight 447.4
Formulation A clear film
Purity >90%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C1CCC[C@H]2CCCN3CC[C@H](CCCCCC[C@H]4CCCN5CC[C@@H](CC1)O[C@H]45)O[C@H]23
InCHI Code 1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24-,25-,26+,27+,28+/m0/s1
InCHI Key PQYOPBRFUUEHRC-SCUYQTRWSA-N |