Autotaxin (human recombinant)

产品编号：	10803-25 查看说明书
产品名称：	Autotaxin (human recombinant) .0 订购此产品
供应商：	Cayman
规格：	25 碌g
目录价：	1568
库存状态：	3周
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Autotaxin (human recombinant) Cayman Chemical Item Number 10803 Description Source: active recombinant C-terminal histidine-tagged protein expressed using a baculovirus overexpression system in Sf21 cells · Mr: 98.8 kDa · Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces various cellular responses.1↗ ATX-LPA signaling is involved in a range of pathologies including tumor progression and inflammation.2↗ ATX is proteolytically processed by cleavage of a 35 amino acid signal peptide and then secreted as a mature protein.3↗ N-glycosylation of ATX at Asn53 and Asn410 is essential for activity and secretion of ATX from adipocytes.1↗ ATX is organized in a modular domain arrangement with a central phosphodiesterase catalytic site, which is similar to the catalytic domain of alkaline phosphatases.4↗ Two cysteine-rich somatomedin B-like domains (involved in protein-protein interactions) are located at the N-terminal portion of the protein followed by an adjacent hydrophobic-containing RGD tripeptide motif that may be involved in cell-extracellular matrix interactions. Finally, a nuclease-like domain is located at the C-terminus, which is catalytically inert and possibly involved in substrate binding and presentation.5↗ Synonyms ENPP-2,Lysophospholipase D,Ectonucleotide Pyrophosphatase/Phosphodiesterase-2 Formulation A solution in 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol Purity ≥95% Stability 9 months Storage -80°C Shipping Dry ice in continental US; may vary elsewhere
保存条件：	-80°C
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