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azido-FTY720
Cayman Chemical Item Number 10008612
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗ FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).2↗ Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.3↗ azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.4↗
Formal Name 2-amino-2-[2-(4-(1-azido-2-octylphenyl))ethyl]-1,3-propanediol
CAS Number 881914-35-8
Molecular Formula C19H32N4O2
Formula Weight 348.5
Formulation A solution in ethanol
Purity ≥98%
λmax 213, 252, 284 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1CN=[N]=N
InCHI Code 1S/C19H32N4O2/c1-2-3-4-5-6-7-8-17-10-9-16(13-18(17)22-23-21)11-12-19(20,14-24)15-25/h9-10,13,24-25H,2-8,11-12,14-15,20H2,1H3
InCHI Key FLPFGLNTCQQHNS-UHFFFAOYSA-N |