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BAY-43-9006
Cayman Chemical Item Number 10009644
Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer.1↗ BAY-43-9006 is an inhibitor of Raf-1 and B-Raf (IC50 = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including vascular endothelial growth factor receptors 2 and 3, platelet-derived growth factor receptor β, Flt-3, and c-KIT (IC50 = 90, 15, 20, 57, and 58 nM, respectively).1↗,2↗ It poorly inhibits ERK-1, MEK-1, and several other kinases (IC50 >10 μM). Through these effects BAY-43-9006 inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in renal cell carcinoma and hepatocellular carcinoma.3↗,4↗,5↗,6↗
Synonyms Nexovar® Sorafenib
Formal Name 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
CAS Number 284461-73-0
Molecular Formula C21H16ClF3N4O3
Formula Weight 464.8
Formulation A crystalline solid
Purity ≥98%
λmax 204, 266 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(NC)C1=NC=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=C1
InCHI Code 1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
InCHI Key MLDQJTXFUGDVEO-UHFFFAOYSA-N
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