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BAY-11-7082
Cayman Chemical Item Number 10010266
Description:The transcription factor NF-κB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules.1↗ In the cytoplasm, inactive NF-κB complexes are bound to an inhibitor IκB.2↗ However in response to certain stimuli, IκB is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-κB to the nucleus.3↗ BAY-11-7082 selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation.4↗ This compound inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM.4↗
Formal Name 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
CAS Number 19542-67-7
Molecular Formula C10H9NO2S
Formula Weight 207.3
Formulation A crystalline solid
Purity ≥98%
λmax 251 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES N#C/C=C/S(=O)(=O)c1ccc(C)cc1
InCHI Code 1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InCHI Key DOEWDSDBFRHVAP-KRXBUXKQSA-N |