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BAY-41-8543 Exclusive
Cayman Chemical Item Number 10011131
Description Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY-41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold.1↗ Surprisingly, NO donors synergize with BAY-41-8543 in stimulating recombinant sGC.1↗ BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations.1↗In vivo, BAY-41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis.2↗ Inhalation of microparticles containing BAY-41-8543 increases pulmonary vasodilation without changing mean arterial pressure,3↗ suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension.
Formal Name 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
CAS Number 256498-66-5
Molecular Formula C21H21FN8O
Formula Weight 420.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES FC(C=CC=C1)=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=C2N=CC=C5
InCHI Code 1S/C21H21FN8O/c22-15-6-2-1-4-13(15)12-30-21-14(5-3-7-25-21)16(28-30)20-26-18(23)17(19(24)27-20)29-8-10-31-11-9-29/h1-7H,8-12H2,(H4,23,24,26,27)
InCHI Key AQYFUZRYBJBAGZ-UHFFFAOYSA-N |