|
Berberine
Cayman Chemical Item Number 10006427
Description
Berberine is a widely distributed berberidaceaen alkaloid that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.1↗ Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.
Synonyms BBR
Umbellatine
Formal Name 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, chloride
CAS Number 633-65-8
Molecular Formula C20H18ClNO4
Formula Weight 371.8
Formulation A crystalline solid
Purity ≥95%
λmax 230, 266, 348, 431 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES COC1=C2C(C=C3[N+](CCC4=C3C=C5C(OCO5)=C4)=C2)=CC=C1OC.[Cl-]
InCHI Code 1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InCHI Key VKJGBAJNNALVAV-UHFFFAOYSA-M |