Candesartan cilexetil

产品编号：	10489-500 查看说明书
产品名称：	Candesartan cilexetil .0 订购此产品
供应商：	Cayman
规格：	500 mg
目录价：	924
库存状态：	3周
CAS编号：	145040-37-5
应用范围：
种属来源：
相关信息：
Candesartan cilexetil Cayman Chemical Item Number 10489 Description Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.1↗ Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.2↗ In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.3↗ Synonyms TCV-116 Formal Name 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester-1H-Benzimidazole-7-carboxylic acid CAS Number 145040-37-5 Molecular Formula C33H34N6O6 Formula Weight 610.7 Formulation A crystalline solid Purity ≥98% Stability 2 years Storage -20°C Shipping Wet ice in continental US; may vary elsewhere SMILES O=C(OC(C)OC(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)=O)OC6CCCCC6 InCHI Code 1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38) InCHI Key GHOSNRCGJFBJIB-UHFFFAOYSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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