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CAY10444 Exclusive
Cayman Chemical Item Number 10005033
Description
A family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned.1↗,2↗ S1P3/EDG3 is a member of this family that is widely expressed in many tissues, signaling via the ERK-½ and PLC/IP3 pathways. CAY10444 is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 µM.3↗
1 Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta 1582 72-80 (2002).
2 Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).
3 Koide, Y., Hasegawa, T., Takahashi, A., et al. Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. J Med Chem 45 4629-4638 (2002).
Synonyms BML-241
Formal Name 2-undecyl-thiazolidine-4-carboxylic acid
CAS Number 298186-80-8
Molecular Formula C15H29NO2S
Formula Weight 287.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES [H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O
InCHI Code 1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18)
InCHI Key FNBSOIBCKUUVJJ-UHFFFAOYSA-N |