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CAY10464Exclusive
Cayman Chemical Item Number 10006545
Description
The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar.1↗ CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations.2↗ It is inactive as an estrogen receptor ligand even at 100 µM.
Formal Name 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number 688348-37-0
Molecular Formula C15H12Cl2O
Formula Weight 279.2
Formulation A crystalline solid
Purity ≥98%
λmax 212, 326 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1
InCHI Code 1S/C15H12Cl2O/c1-18-15-6-4-11(5-7-15)2-3-12-8-13(16)10-14(17)9-12/h2-10H,1H3/b3-2+
InCHI Key YDVZIQMQLZBUKX-NSCUHMNNSA-N |