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CAY10498
Cayman Chemical Item Number 10007955
Description
The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation.1↗ A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively.1↗ CAY10498 is also a structural analog of reversine, a dedifferentiation agent of embryonic progenitor cells.2↗ However, no dedifferentiation effects or any connection between A3 AR antagonism and dedifferentiation have been demonstrated.
Synonyms 2-phenyl-amino-N6-endo-norbornyladenine
Formal Name 1H-Purine-2,6-diamine, N6-(1R,2S,4S)-bicyclo[2.2.1]hept-2-yl-N2-phenyl
CAS Number 863202-33-9
Molecular Formula C18H20N6
Formula Weight 320.4
Formulation A solution in ethanol
Purity ≥98%
λmax 257 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES c1ccc(cc1)Nc1nc(NC2CC3CCC2C3)c2nc[nH]c2n1
InCHI Code 1S/C18H20N6/c1-2-4-13(5-3-1)21-18-23-16-15(19-10-20-16)17(24-18)22-14-9-11-6-7-12(14)8-11/h1-5,10-12,14H,6-9H2,(H3,19,20,21,22,23,24)
InCHI Key SLLSODGWHDUMRG-UHFFFAOYSA-N |