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CAY10508
Cayman Chemical Item Number 10008669
Description Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective CB1 receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM.1↗ A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.
Formal Name 1,3-bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione
CAS Number 878533-35-8
Molecular Formula C21H14Br2N2O2
Formula Weight 486.2
Formulation A crystalline solid
Purity ≥98%
λmax 248 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES Brc1ccc(cc1)N1C(=O)C(c2ccccc2)N(c2ccc(Br)cc2)C1=O
InCHI Code 1S/C21H14Br2N2O2/c22-15-6-10-17(11-7-15)24-19(14-4-2-1-3-5-14)20(26)25(21(24)27)18-12-8-16(23)9-13-18/h1-13,19H
InCHI Key ROASQEPZAKGACK-UHFFFAOYSA-N |