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CAY10561 Exclusive
Cayman Chemical Item Number 10010043
Description
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.1↗ CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).2↗ This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM).2↗ CAY10561 inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.2↗
Synonyms Pyrazolylpyrrole ERK Inhibitor
Formal Name N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide
CAS Number 933786-58-4
Molecular Formula C22H17Cl2FN4O2
Formula Weight 459.3
Formulation A crystalline solid
Purity ≥98%
λmax 270 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES [H]N1C(C2=CNC(C(NC(CO)C3=CC=C(F)C(Cl)=C3)=O)=C2)=C(C4=CC(Cl)=CC=C4)C=N1
InCHI Code 1S/C22H17Cl2FN4O2/c23-15-3-1-2-12(6-15)16-10-27-29-21(16)14-8-19(26-9-14)22(31)28-20(11-30)13-4-5-18(25)17(24)7-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31)
InCHI Key YMUYGRBBEDYUOP-UHFFFAOYSA-N |