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CAY10573Exclusive
Cayman Chemical Item Number 10008846
Description
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively.1↗ CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM).1↗
Formal Name 5-[3-[(6-benzoyl-1-propyl-2-naphthalenyl)oxy]propoxy]-1H-indole-1-acetic acid
CAS Number 853652-40-1
Molecular Formula C33H33NO5
Formula Weight 521.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCc1c(OCCCOc2ccc3ccn(CC(=O)O)c3c2)ccc2cc(ccc12)C(=O)c1ccccc1
InCHI Code 1S/C33H31NO5/c1-2-7-29-28-14-11-26(33(37)24-8-4-3-5-9-24)20-25(28)12-15-31(29)39-19-6-18-38-27-13-10-23-16-17-34(22-32(35)36)30(23)21-27/h3-5,8-17,20-21H,2,6-7,18-19,22H2,1H3,(H,35,36)
InCHI Key PMPUMRAPFFYFRW-UHFFFAOYSA-N |