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CAY10597
Cayman Chemical Item Number 10012539
Description
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2.1↗ CAY10597 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM.2↗ The R enantiomer of CAY10597 is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.2↗
Formal Name 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid
CAS Number 916046-55-4
Molecular Formula C20H14ClFN2O5
Formula Weight 416.8
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES OC(=O)CN1c2ccc(Cl)cc2C2(CC(=O)N(Cc3ccccc3F)C2=O)C1=O
InCHI Code 1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)
InCHI Key SKLDVYDFQCXARY-UHFFFAOYSA-N |