CAY10607

产品编号：	10012694-1 查看说明书
产品名称：	CAY10607 .0 订购此产品
供应商：	Cayman
规格：	1 mg
目录价：	1509.2
库存状态：	3周
CAS编号：	1012788-65-6
应用范围：
种属来源：
相关信息：
CAY10607 Exclusive Cayman Chemical Item Number 10012694 Description Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. CAY10607 binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM).1↗ In addition, CAY10607 inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.1↗ Synonyms BHI Benzisoxazole Hsp90 Inhibitor Formal Name 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-1,3-benzenediol CAS Number 1012788-65-6 Molecular Formula C19H20ClN3O4 Formula Weight 389.8 Formulation A crystalline solid Purity ≥98% λmax 230, 316, 359 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES Oc1cc(O)c(cc1Cl)c1noc2ccc(NCCN3CCOCC3)cc12 InCHI Code 1S/C19H20ClN3O4/c20-15-10-13(16(24)11-17(15)25)19-14-9-12(1-2-18(14)27-22-19)21-3-4-23-5-7-26-8-6-23/h1-2,9-11,21,24-25H,3-8H2 InCHI Key JLIRVZVVCCIAKG-UHFFFAOYSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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