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D-myo-Inositol-1,2,3,6-tetraphosphate (sodium salt)
Cayman Chemical Item Number 10008450
Description
D-myo-Inositol-1,2,3,6-tetraphosphate (Ins(1,2,3,6)-P4) is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals.1↗,2↗,3↗ The most studied InsP, Ins(1,4,5)-P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.4↗,5↗ Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.5↗,6↗ Ins(1,2,3,6)-P3 (tested as the meso compound) is 100-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.7↗
Synonyms 1,2,3,6-IP4 (sodium salt)
Ins(1,2,3,6)-P4 (sodium salt)
Formal Name D-myo-Inositol-1,2,3,6-tetrakis (dihydrogen phosphate), tetrasodium salt
Molecular Formula C6H12O18P4 · 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@@H]1[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
InCHI Code 1S/C6H16O18P4.4Na/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;/q;4*+1/p-4/t1-,2-,3?,4?,5?,6?;;;;/m0..../s1
InCHI Key DZJJWPAQUIBBLR-CZKBEOFPSA-J |