|
D-myo-Inositol-1,2,6-triphosphate (sodium salt)
Cayman Chemical Item Number 10007780
Description
D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.1↗,2↗ The most studied InsP, Ins(1,4,5)-P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3↗,4↗ Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4↗,5↗ Ins(1,2,6)-P3 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.6↗
Synonyms Ins(1,2,6)-P3
1,2,6-IP3
Formal Name D-myo-inositol-1,2,6-tris(hydrogen phosphate), trisodium salt
Molecular Formula C6H12O15P3 · 3Na
Formula Weight 486.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@H]1[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H]1O.[Na+].[Na+].[Na+]
InCHI Code 1S/C6H15O15P3.3Na/c7-1-2(8)4(19-22(10,11)12)6(21-24(16,17)18)5(3(1)9)20-23(13,14)15;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3+,4?,5?,6?;;;
InCHI Key JENABGGDGLKLTB-AJBPOAAQSA-K |