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MDP Rhodamine
Rhodamine-labeled MDP
Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1,2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs2. The potent adjuvant activity of MDP may also be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3].
MDP Rhodamine is coupled via a 6-aminohexanoic acid spacer molecule at the C6 position of the muric acid. This spacer linker arm minimizes potential steric hindrance effects.
Specificity: NOD2 agonist
Working concentration: 1 - 10 µg/ml
Endotoxin level: EndoFit™
Solubility: DMSO (10 mg/ml)
Molecular weight: 1141.72
Spectral Properties of Rhodamine
Excitation λ max: 552 nm
Emission λ max: 570 nm |