C12-iE-DAP

C12-iE-DAP
Acylated derivative of iE-DAP
C12-iE-DAP is an acylated derivative of the dipeptide iE-DAP (γ-D-Glu-mDAP), present in the peptidoglycan (PGN) of Gram-negative bacilli and particular Gram-positive bacteria. C12-iE-DAP is recognized by the intracellular sensor NOD1, which results in NF-κB activation and the production of inflammatory cytokines. C12-iE-DAP stimulates NOD1 at concentrations 100- to 1000-fold lower than iE-DAP. C12-iE-DAP provided by InvivoGen is chemically synthesized and tested using HEK-Blue™ NOD1.
Note: C12-iE-DAP is a mixture of Lauroyl-g-D-Glu-D-mDAP and Lauroyl-g-D-Glu-L-mDAP.
C12-iE-DAP is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: NOD1 agonist
Working concentration: 1 ng - 1 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/μg)
Solubility: 10 mg/ml DMSO or methanol
Synonym: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid
Formula: C24H43N3O8
Molecular weight: 501.61