Bay11-7082 NLRP3 Inflammasome Inhibitor - IκB-α Inhibitor Bay 11-7082 is an irreversible inhibitor of TNF-α-induced IκB-α phosphorylation resulting in the inactivation of NF-κB [1]. TNF-α-dependent effects of NF-κB are important for TLR expression and cytokine production [2,3]. Moreover Bay11-7082 selectively inhibit NLRP3 inflammasome activity in macrophages independent of their inhibitory effect on NF-κB activity [4]. Working concentration: 1-10 μM Purity: >99% (HPLC) CAS number: 195462-67-7 Molecular weight: 207.3 Solubility: 25 mg/ml in DMSO and 15 mg/ml in ethanol
