ODN 2006 FITC FITC labeled CpG oligonucleotide - Human TLR9 ligand CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs). These CpG motifs are present at a 20-fold greater frequency in bacterial DNA compared to mammalian DNA. They have been shown to induce a coordinated set of immune responses based on the activation of immune cells primarily involved in the recognition of these molecules. ODN 2006 FITC is a CpG ODN class B specific for human TLR9. ODN 2006 FITC can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry. Synonyms: ODN 7909, PF_3512676 Specificity: human TLR9 agonist Working concentration: 10 ng -10 μg/ml ODN 2006 sequence 5’- tcgtcgttttgtcgttttgtcgtt -3’ (24 mer) Note: Bases are phosphorothioate (nuclease resistant). Spectral Properties of FITC Excitation λ max: 495 nm Emission λ max: 520 nm
