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Geldanamycin
An inhibitor of the heat-shock protein Hsp 90
Geldanamycin (GA) is a natural product produced by Streptomyces hygroscopicus.
InvivoGen produces GA from a mutant strain of S. hygroscopicus, inactivated for the synthesis of nigericin, a common contaminant of GA.
GA binds with high affinity into the ATP binding pocket of Hsp90. Hsp90 is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and/or survival of tumor cells.
Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1a (HIF-1a) [1]. Binding of GA to Hsp90 causes the destabilization and degradation of its client proteins [2].
Working concentration: 1 nM - 10 μM
CAS number: 30562-34-6
Formula: C29H40N2O9
Molecular weight: 560
Solubility: Soluble in DMSO (1 mg/ml)
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