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产地：sigma
货号：T1952-200ul
规格：200ul
英文名称：Trichostatin A, Ready Made Solution
别名: TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
CAS号: 58880-19-6
Biochem/physiol Actions
Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo.1 Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription.2,3 TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.4
相关类型 Antibiotic Ready Made Solutions, Antibiotics, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cell Biology,
Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, Reagents, T, Tools for Gene Regulation Research
biological source from Streptomyces sp.
form DMSO solution
concentration 5 mM in DMSO (0.2 μm-filtered)
shipped in dry ice
storage temp. −20°C |