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中文名:环孢多肽A;环孢灵;环孢霉素A;赛斯平;山地明 ,环孢素,新山地明,环孢素A
英文名:Ciclosporin A ,CsA, Cs-A, CY-A, Sandimmune, Ciclosporin, Cyspin.
Sigma相关产品资料:
Sigma C3662 Cyclosporin A
from Tolypocladium inflatum, ≥95% (HPLC), solid
Synonym: Antibiotic S 7481F1, Cyclosporine
CAS Number: 59865-13-3
Linear Formula: C62H111N11O12
Molecular Weight: 1202.61
Beilstein Registry Number: 3647785
MDL number: MFCD00274558
PubChem Substance ID: 24278028
Description
Biochem/physiol Actions A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Properties
biological source from Tolypocladium inflatum
assay ≥95% (HPLC)
form solid
color white
solubility dichloromethane: 10 mg/mL
ethanol: 10 mg/mL
DMSO: 50 mg/mL
chloroform: 6 mg/mL
H2O: insoluble
Gene Information human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)
storage temp. 2-8°C |