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英文名Hydrocortisone
中文名: 可的索;皮质醇;氢化皮质酮;氢可的松 ,氢化可的松
说明:类别肾上腺皮质激素及促肾上腺皮质激素药
Sigma相关产品资料：
Sigma H0888 Hydrocortisone
cell culture tested
Synonym: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
CAS Number: 50-23-7
Linear Formula: C21H30O5
Molecular Weight: 362.46
Beilstein Registry Number: 1354819
EC Number: 200-020-1
MDL number: MFCD00011654
PubChem Substance ID: 24895415
Description
Reconstitution To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.
Physical form powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
性质
assay ≥98%
potency 0.004-5 μg/mL
mp 211-214 °C(lit.)
suitability cell culture tested
Gene Information human ... ABCB1(5243), CYP3A4(1576), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
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