中文名: 雷帕霉素;西罗莫司英文名: Sirolimus;Rapamycin；AY 22989；FRAP；FAFTRapamycin也称AY 22989或sirolimus，可与FKBP12形成复合物，随后结合并抑制FRAP/mTOR。mTOR是哺乳动物中rapamycin的作用靶点，也被称为FRAP或FAFT，是一个Ser/Thr蛋白激酶，可以激活p70 S6 kinase。Rapamycin对于p70 S6 kinase的抑制作用的IC50为0.05nM。Rapamycin通过抑制FRAP/mTOR可以抑制p70 S6 kinase的磷酸化和激活，抑制4E-BP1/PHAS1的磷酸化并促进其对eIF4E的结合和抑制。LC Laboratories相关资料如下:R-5000 Rapamycin, >99%M.W. 914.17 C51H79NO13 [53123-88-9]RTECS: VE6250000 M.I. 12: 8288 M.I. 14: 8114Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol (up to about 50 mg/mL for either solvent). Disposal: AView the MSDS for this product:• Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein.&
