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中文名称: 花生四烯酸,花生油烯酸 ，全顺式-5，8，11，14-二十碳四烯酸AA
英文名称:Arachidonic acid ,ARA cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid
Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid
5,8,11,14-Eicosatetraenoic Acid
5,8,11,14-Icosatetraenoic Acid
化学名称: (all-Z)-5,8,11,14-Eicosatetraenoic acid
分 子 式: C20H32O2
分 子 量: 304.46
说明:花生四烯酸是（全顺式-5，8，11，14-二十碳四烯酸）化学式如下：CH3(CH2)4(CH=CH-CH2)4(CH2)2COOH 属于不饱和脂肪酸，其中含有四个碳-碳双键，一个碳-氧双键。
药理作用:具有兴奋子宫的作用[3～5]。能延长大鼠妊娠[6]。对胃酸的分泌有抑制活性[7]。
用 途: 安定, 抗消化性溃疡及胃肠功能障碍, 作用于子宫 。花生四烯酸是人体大脑和视神经发育的重要物质，对提高智力和增强视敏度具有重要作用。 花生四烯酸具有酯化胆固醇、增加血管弹性、降低血液粘度，调节血细胞功能等一系列生理活性。 花生四烯酸对预防心血管疾病、糖尿病和肿瘤等具有重要功效。
Simga相关产品资料
Sigma 10931 Arachidonic acid
>95.0% (GC)
Synonym: cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid, Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid
CAS Number: 506-32-1
Linear Formula: CH3(CH2)4(CH=CHCH2)4CH2CH2CO2H
Molecular Weight: 304.47
Beilstein Registry Number: 1713889
EC Number: 208-033-4
MDL number: MFCD00004417
PubChem Substance ID: 24846907
Description
Biochem/physiol Actions Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the α subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
Quality Sigma-Aldrich will change the name of this product, eliminating the term "puriss." or "purum" beginning October, 2009. Please note that this is only a name change; the product qualities and specifications remain the same.
Properties
assay >95.0% (GC)
refractive index n20/D 1.4872(lit.)
bp 169-171 °C/0.15 mmHg(lit.)
mp −49 °C(lit.)
density 0.922 g/mL at 25 °C(lit.)
shipped in dry ice
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Risk Statements 19
WGK Germany 3
RTECS CE6675000
Flash Point(F) 235 °F
Flash Point(C) 113 °C |