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ZM 336372
N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
产品信息
Form Off-white solid
Primary Target protein kinase c-Raf
Primary Target IC50 70 nM
Secondary target SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM)
Molar mass 389.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C23H23N3O3
CAS number 208260-29-1
Declaration Sold under license of PCT Application W098/22,103.
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |