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688001 InSolution™ Y-27632
Rho Kinase Inhibitor VI
A highly potent, cell-permeable, selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 mM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips).
产品信息
Form Liquid
Formulation A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H2O.
Primary Target p160ROCK
Primary Target Ki 140 nM
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C14H21N3O · 2HCl · H2O
Declaration Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Harmful
安全标示
S Phrase S: 36
Wear suitable protective clothing.
R Phrase R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed |