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VEGFR3 Kinase Inhibitor, MAZ51
3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, MAZ51, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
A cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
产品信息
Form Red solid
Primary Target VEGF receptor tyrosine kinase
Molar mass 314.1
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H18N2O
CAS number 163655-37-6
Declaration Not available for sale in Germany.
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |