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VEGFR2 Kinase Inhibitor II
(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII
A membrane permeant and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Does not inhibit EGF-R kinase activity (IC50 > 100 µM).
产品信息
Form Brown solid
Primary Target VEGF-R2 (KDR/Flk-1)
Primary Target IC50 70 nM
Secondary target 920 nM for PDGF-Rb, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1
Molar mass 343.2
Protect from Light 是的
Packaged under inert gas 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C17H15BrN2O
CAS number 288144-20-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |