TUMOR NECROSIS FACTOR-A, HUMAN, RECOMB.

TNF-α, Human, Recombinant, E. coli
rhTNF-α, rh-Cachectin, Tumor Necrosis Factor-α
Recombinant, human tumor necrosis factor-α expressed in E. coli. A cytokine produced primarily by activated macrophages that activates a variety of immune defense mechanisms by interactions with polymorphonuclear leukocytes, T cells, antibody-producing B lymphocytes, fibroblasts, and hematopoietic bone marrow cells. Activity is not species-specific. Induces apoptosis in human blood and bone marrow neutrophils and in endothelial cells. Increases the iNOS levels in vascular smooth muscle cells. Involved in pathophysiological processes of several chronic and acute diseases. Stimulates stress activated protein kinase (SAPK).
产品信息
Form  Lyophilized
Formulation  Carrier-free
Molar mass  17500
Biological activity  ED50 = 20-50 pg/ml as measured in a cytotoxicity assay with the TNF-α-susceptible murine L-929 cell line in the presence of Actinomycin D (Cat. No. 114666)
Purity  ≥95% by SDS-PAGE
Contaminants  Endotoxin: ≤0.1 ng/µg TNF-α
Solubility  Sterile, dH2O
RTECS  MT6435000
CAS number  94948-59-1
商店和运输信息
Storage  ≤ -70°C
Ship  Ambient Temperature Only
Standard Handling