Troglitazone A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21Cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in the sarcoplasmic reticulum and inhibits Na+/H+ exchange activity and proliferation of macrovascular endothelial cells. 产品信息 Form Yellow solid Molar mass 441.5 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥98% by TLC Solubility DMSO or EtOH Chemical formula C24H27NO5S RTECS XJ5813130 CAS number 97322-87-7 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling
