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SB 290157
N2-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
产品信息
Form Lyophilized
Molar mass 526.5
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C22H28N4O4 · CF3CO2H
CAS number 1140525-25-2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |