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SB 220025
5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
This product has been discontinued.
We are offering SB 220025, Trihydrochloride (Cat. No. 559408)as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
产品信息
Form Pale yellow solid
Primary Target P38MAPK
Primary Target IC50 60 nM
Molar mass 338.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C18H19FN6
CAS number 165806-53-1
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |