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Rb/Raf-1 Disruptor 251
S-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251
A cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction (IC50 = 77 nM in cell-free binding assays), while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/prohibitin, Rb/cyclin E, Rb/HDAC1, Raf-1/MEK1, or Raf-1/MEK2 interaction. Suppresses cellular E2F transcription activity and reduces serum-induced Rb phosphorylation. Shown to display Rb-dependent antitumor activity both in cultures in vitro and in mice in vivo.
产品信息
Form White solid
Molar mass 271.6
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C8H9Cl3N2S
CAS number 72214-67-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant |