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Rottlerin
Mallotoxin
A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
产品信息
Form Orange solid
Primary Target PKCδ
Primary Target IC50 3-6 µM
Secondary target PKCα, PKCβ, and PKCγ (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM)
Molar mass 516.5
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C30H28O8
RTECS AM6913800
CAS number 82-08-6
Merck USA index 14, 8272
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |