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Reversine
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine, MLCK Inhibitor V, Aurora Kinase Inhibitor V, CD45 Inhibitor II, PTP Inhibitor XIII, VHR Inhibitor I
A cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 µM. The first organic molecule that has been demonstrated to reverse the cellular differentiation process. Acts as a selective A3 adenosine receptor antagonist (Ki = 660 nM, >10 µM, and >10 µM for hA3, hA1, and hA2A, respectively. Functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). Also acts as an ATP-competitive, reversible and selective inhibitor of Aurora Kinases A, B and C (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel. Shown to be a potent, selective, and ATP-competitive inhibitor of MPS1 (IC50 = 2.8 nM, full-length enzyme).
产品信息
Form Off-white solid
Molar mass 393.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H27N7O
CAS number 656820-32-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |