Rac1 Inhibitor A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively). 产品信息 Form Lyophilized Molar mass 530.96 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥93% by HPLC Solubility H2O Chemical formula C24H38Cl3N7 CAS number 1177865-17-6 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Carcinogenic / Teratogenic