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Raf Kinase Inhibitor VI
1,7-Dibenzyl-8-(2-hydroxyethylsulfanyl)-3-methyl-purine-2,6-dione
A purine-2,6-dione compound that targets the ATP-binding pocket of B-Raf and effectively inhibits the phosphorylation of MEK by wild-type B-Raf in cell-free in vitro kinase assays (IC50 = 1.7 µM and Ki, app = 106 nM with 100 µM ATP). Reported to be equally potent against the oncogenic V600E B-Raf mutant and exhibit much less activity against PI 3-Kγ (IC50 = 25 µM) and more than 50-fold selectivity over PAK1, GSK-3β, PAK4, MST1, and PIM1 (IC50 ≥ 100 µM).
产品信息
Form White solid
Molar mass 422.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C22H22N4O3S
CAS number 331444-40-7
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling |