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Raf1 Kinase Inhibitor I
5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
产品信息
Form Dark orange solid
Primary Target CRAFI kinase
Primary Target IC50 9 nM
Molar mass 520.9
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C15H8Br2INO2
CAS number 220904-83-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |