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PTP CD45 Inhibitor
N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, PTEN Inhibitor V, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, SF1670
A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
产品信息
Form Red-violet solid
Primary Target CD45 using pNPP as a substrate
Primary Target IC50 200 nM
Secondary target CD45 (IC50 = 3.8 µM using phosphorylated Ick505 peptide as a substrate
Molar mass 307.3
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥ 97% by HPLC
Solubility DMSO or EtOH
Chemical formula C19H17NO3
CAS number 345630-40-2
商店和运输信息
Storage +2°C to +8°C
Ship Blue Ice Only
Harmful |