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PTP1B Inhibitor
3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
A cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749).
产品信息
Form White solid
Primary Target PTP1B403
Primary Target IC50 4 µM
Secondary target IC50 = 8 µM for PTP1B298
Molar mass 741.5
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C26H19Br2N3O7S3
CAS number 765317-72-4
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |